| || |
Buy Tetracycline Hydrochloride
Buy Tetracycline Hydrochloride
Special Internet Prices.
Fast & Guaranteed Worldwide Delivery!
Secure & FAST Online Ordering.
Our Drugstore Is The Most Trusted Online Drug Supplier.
Related post: 1882). The toxicity is low, the fatal dose per vein for dogs being about i Gm. per
kilogram. Methyl and ethyl salicylates intravenously produce pulmonary edema by
injuring the capillary walls.
Therapeutic Effects in Rheumatic Fever and Rheumatic Tonsillitis.
The proper administration of salicylates controls the manifestations of
this disease in a most remarkable manner in nearly all typical cases
so uniformly that failure throws suspicion on the diagnosis: the pain and
fever disappear; the local inflammation, the immobility, swelling and red-
ness subside; the general condition of the patient is vastly improved;
and the disease is under complete control in one to at most five days.
These benefits last only so long as the patient is kept salicylated and
relapses occur when this is discontinued. According to statistics, the
total duration of the disease, as judged by the stay in the hospital, is not
affected (J. L. Miller, 1914).
The rheumatic cardiac lesions are not relieved directly (Vulpian, 1880).
Indirectly the salicylate treatment doubtless has an important tendency
in this direction by favoring rest and avoiding the extra tax of fever, pain
Efficiency in Related Conditions. Salicylates are much less certain
in atypical subacute, chronic, and muscular rheumatism, lumbago,
etc., although they usually have some analgesic effect. In acute gout
they are often quite effective (Vulpian, 1880). They are notably ineffi-
cient in scarlatinal and gonorrheal arthritis (G. See, 1877 ; Stockman, 1906).
They are also used in headache, neuralgias, sciatica, tabes and other similar
pains, but with inconstant results. In chorea it is difficult to prove any
Response in Different Affections. In the routine statistics of Hanzlik, 1913, in
132 cases of rheumatic fever, salicylates gave complete relief in 82 per cent., partial
relief in 16.5 per cent., and failed' in only 1.5 per cent. In subacute rheumatism,
thirty cases, it gave complete relief in 53 per cent.; partial in 30 per cent.; failures in 17
per cent. In sciatica, eleven cases, it did not give complete relief in any, failed com-
pletely in 27 per cent., and afforded partial relief in 73 per cent.
Mechanism, of Action. This has been attributed to the general anal-
gesic effect; and to a specific germicidal action on the hypothetic organisms
of rheumatic fever. The present data do not suffice to establish either
of these views.
The enormous doses which are required; the small efficiency of other
antipyretics and analgesics; the relative inefficiency of the salicylates in
other forms of arthritis all these facts point to a specific action on the
Against this view speak the prompt recurrence of the symptoms if
the salicylate is discontinued and the failure to prevent the cardiac
infection. In rabbits, the prophylactic use of salicyl does not prevent or
even influence arthritis from intravenous injection of rheumatic hemolytic
streptococci (Miller, 1914; Davis, 1915); but this is not conclusive since
the etiology has not been established, and the administration is very
different. The analgesic explanation is based on the limited efficiency of
SALICYLIC COMPOUNDS 501
salicylates in other painful conditions (Laborde, 1877; Vulpian, 1880);
and on the effect of other analgesics in rheumatic fever.
Administration. For internal use, the free salicylic acid is too irritant.
The sodium salicylate is the most commonly used, notwithstanding its
mawkish, nauseant taste. This may be partly disguised by giving the
salt in carbonated water, or flavoring with peppermint or wintergreen
water. The direct gastric irritation is avoided by adding an equal or
double quantity of sodium bicarbonate.
To be effective in acute rheumatism, large doses must be administered:
i to 1.3 Gm. (15 to 20 gr.) should be given every hour until "toxic"
symptoms (tinnitus, nausea, etc.) set in. The administration should then
be stopped for twelve hours. After this, i Gm. (15 gr.) should be given
every four hours for several weeks, keeping the patient in bed as long as
possible. As a prophylactic treatment, i Gm. (15 gr.) may be given three
times a day for a week in every month. If the sodium salicylate is not
tolerated, oil of gaultheria or aspirin may be substituted. Oil of gaul-
theria also gives some relief when applied externally to the affected joints.
Hypodermic injections are used by Seibert, 1911, 10 c.c. of 20 per cent, sodium
salicylate per 100 pounds of body-weight, every twelve hours; to avoid pain, cocain may
be injected before. R. T. Williams, 1913, uses it intramuscularly, 8 per cent., with but
little pain. Considering the prompt absorption, these special methods are usually
Rectal Administration. This is preferred by Heyn, 1914, as being more prompt and
less disagreeable. He gives a cleansing soap-sud enema. When it has taken effect,
it is followed by the salicylate through a rectal tube, inserted 6 to 8 inches. The first
dose is of 8 to n Gm. for men, 6 Gm. for women, in 150 c.c. of water or thin starch,
with i c.c. of Tr. Opii. It may be repeated in twelve hours, but usually one enema per
day suffices. Salicyl appears in the urine within fifteen to thirty minutes.
In very severe cases, the intravenous injection of sodium salicylate may be justified
(Mendel, 1905, 1908). Conner, 1914, uses it, with a small needle to avoid thrombosis,
in doses of i to 2 Gm., every eight to twelve hours. Cernadas, 1915, advises a solution
containing 20 per cent, of sodium salicylate and i per cent, caffein ; injecting this
daily, at first 6 c. c., increasing to 10 c.c. The relief is more prompt, and no bad
effects have been reported; but it would not be justifiable as a routine measure.
"Natural" and Synthetic Salicylates. It is often stated that the syn-
thetic sodium salicylate, owing to the presence of supposed impurities,
is more toxic and less efficient than that prepared from oil of wintergreen
or birch. The evidence for this view, which has been fostered mainly by
interested manufacturers, can not stand critical examination. There need
be no hesitation in employing the much more economical synthetic Tetracycline Hydrochloride Ointment prod-
uct (Rep. Counc. Pharm. Chem., 1913; J.A.M.A., 61: 979).
The literature of the subject and its uncritical status have been fully discussed by
Eggleston, 1912. Various impurities have been announced in synthetic salicylates,
especially cresotic acids, phenol, para-hydroxybenzoic acid, and hydroxy-isophthalic
acid; but the evidence for their presence is not convincing. However this may be,
Hilpert, 1913, showed that at the present time even the cheapest commercial samples
are quite as pure as the most expensive. Waddell, 1911, proved that the effects of
natural and synthetic salicylates on animals are quantitatively alike; and the coopera-
tive clinical tests, instituted by the Counc. Pharm. and Chem., arranged so as to exclude
all bias, showed that their effects on patients are indistinguishable (Hewlett, 1913).
In practice, it is almost impossible to be certain of their source, since the oils of winter-
green or birch are very often adulterated, beginning at the still.
Relation of Constitution to Specific 'Anti-rheumatic Action. Phenol, CeHirOH,
is quite inactive. Benzoic acid, CeHfCC^H, has a limited efficiency. The OH and
CO 2 H groups are both necessary, and must be in the ortho position to obtain the full
efficiency. Derivatives which can be converted into salicylic acid in the organism are
effective, in proportion Buy Tetracycline Hydrochloride to the ease of their conversion; but if the H of either group is
Related links: citrato tamoxifeno mg, buy prednisone online no prescription cheap, no prescription allopurinol, purchase tylenol 3 with codeine, bayer aspirin printable coupons 2011, buy accutane uk, neurontin cost australia, Synthroid .075 Mg, budesonide cap 3 mg/24hr, doxycycline buy online
| || |